SYSTEMIC & DIGESTIVE ENZYMES | 2 MONTH SUPPLY

SerraDefend: Systemic Enzyme Support

Name: SerraDefend: Systemic Enzyme Support
Rating: 4.79 (135 reviews)

$29.97

90 Day Risk-Free

Advanced enzyme support with serrapeptase, nattokinase and 7 additional enzymes to support healthy digestion and systemic enzyme activity.

Serrapeptase + nattokinase — 45,000 SPU of serrapeptase and 700 FU of nattokinase for targeted systemic enzyme and biofilm support.
9-enzyme formula — Includes protease, cellulase, hemicellulase, amylase, glucoamylase & more for broad digestive support.
Enteric-coated serrapeptase — Designed to help protect serrapeptase through the stomach for release further along the digestive tract.
2-month supply — Simple daily enzyme support with 60 servings per bottle.

Vegan • Non-GMO • Gluten & dairy free • Third-party tested

Select Quantity: 60 DAY SUPPLY 1 Bottle

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SerraDefend: Systemic Enzyme Support

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A Different Approach to Enzymes

SYSTEMIC & DIGESTIVE ENZYMES

SerraDefend features serrapeptase and nattokinase for systemic support, plus protease, cellulase, and other enzymes to aid digestion and help break down gut biofilms.

EASY TO SWALLOW CAPSULES

Easy-to-swallow capsules with no chalky texture or unpleasant aftertaste. Designed for daily use and gentle for sensitive stomachs.

100% NATURAL & NON-GMO

Made with clean ingredients and free from gluten, soy, dairy, artificial additives, and genetically modified organisms.

GENTLE DAILY SUPPORT

Targeted support designed to work with your body while remaining easy to tolerate.

Key Ingredients

Serrapeptase

A proteolytic enzyme originally derived from silkworms, serrapeptase helps break down unwanted protein structures and supports healthy circulation and tissue response.

Nattokinase

Sourced from fermented soybeans, nattokinase supports healthy blood flow and assists in breaking down excess fibrin in the body.

Protease

A broad-spectrum enzyme that helps digest protein and supports the breakdown of biofilms and other protein-based debris.

Cellulase

An enzyme that breaks down cellulose, helping to digest plant fibers and support overall gut function.

Hemicellulase

Works alongside cellulase to break down complex plant fibers and support a healthy digestive environment.

Chitosanase

Breaks down chitosan, a structural component in yeast cell walls, helping to disrupt biofilms and support microbial balance.

Amylase

A digestive enzyme that helps break down starches and carbohydrates into simpler sugars for better absorption.

Glucoamylase

Works with amylase to further break down complex carbohydrates, supporting healthy digestion and nutrient availability.

Beta-Glucanase

Targets beta-glucans found in fungal cell walls and grains, aiding in biofilm disruption and digestive comfort.

Easy Returns

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90-Day Money Back Guarantee

Product Information

Targeted Enzymes for Gut and Beyond

SerraDefend is a systemic and digestive enzyme formula designed to support gut health, proteolytic enzyme activity, and microbial balance as part of a daily wellness routine.

Powerful Proteolytic Enzyme Blend

Each capsule delivers serrapeptase and nattokinase, two well-known proteolytic enzymes, alongside a supporting blend of protease, cellulase, chitosanase, beta-glucanase, amylase, glucoamylase, and hemicellulase. Together, these enzymes help break down proteins, fibers, and other compounds as part of healthy digestive function.

Support for Digestion and Microbial Balance

SerraDefend is designed for adults looking to support digestive wellness, systemic enzyme support, and a balanced gut environment. It pairs well with a probiotic or broader gut health routine.

Clean Formula with Enteric Coated Serrapeptase

Our enteric coating help protect the serrapeptase from stomach acid as it passes through the digestive tract. SerraDefend is vegan, non-GMO, and free from gluten and dairy.

Third-Party Tested and Made in the USA

Every batch is manufactured in a GMP-certified facility and third-party tested for purity and quality, so you can feel confident about what you’re putting in your body.

Frequently Asked Questions

SerraDefend combines systemic and digestive enzymes into one powerful formula designed to work both in your gut and throughout your body. It features serrapeptase and nattokinase—two well-studied enzymes known for breaking down proteins, fibrin, and biofilms—alongside a full spectrum of digestive enzymes. Unlike basic enzyme blends, SerraDefend is formulated for both digestive support and whole-body benefits like inflammation reduction and improved circulation. It’s made in the USA, third-party tested, vegan, and free of common allergens.

SerraDefend is rigorously tested both in-house and by an independent third-party lab. Every batch is made in GMP-certified facilities that meet the highest standards for safety and quality.

SerraDefend is made in California, USA, using high-quality ingredients sourced from around the world, in a GMP-certified, FDA-compliant facility. We use rigorous quality control on our ingredients and processes to ensure the highest standards.

SerraDefend is completely free of nuts, wheat, gluten, soy, and dairy. It is vegan, completely non-GMO, and free from all preservatives and artificial colors or flavors. Our facilities are fully cGMP-compliant and operate to the highest standards. In addition, we use rigorous quality control to ensure that our supplements match what it says on the label.

SerraDefend does not need to be refrigerated. However, it will stay freshest when stored in a cool, dry place.

We recommend taking SerraDefend without food and at least one hour away from your meal. That will allow the systemic enzymes to pass through to your intestine safely. The exact time of day does not matter, but it should be at least an hour away from any meal.

The capsules we use for SerraDefend are 0.72in long and 0.42in wide. They're quite compact and most of our customers find them very easy to swallow.

Most people notice improvements within 1–2 weeks of consistent use, but this can vary depending on your health goals and how you're using SerraDefend (with or without food). For best results, we recommend taking it daily on an empty stomach, for at least 4–6 weeks.

For some people, enzyme formulations like SerraDefend can cause mild digestive symptoms at first. They might include gas, bloating or mild diarrhea. These symptoms usually pass within a few days.

If you are pregnant or breastfeeding, please consult your healthcare provider before using SerraDefend or any other supplement.

Why Choose Balance One?

Quality you can feel confident about, from formulation to finished product.

90-day money-back guarantee

Try it risk-free. If Balance ONE isn’t right for you, you’re covered by our 90-day money-back guarantee.

Third-party tested

Our supplements are independently tested to help verify quality and purity.

No proprietary blends

We clearly show the active ingredients and amounts, so you know exactly what you’re taking.

Made for everyday use

Clear serving directions and practical formats make our supplements easy to fit into your routine.

5 stars: 116 (86%)
4 stars: 13 (10%)
3 stars: 4 (3%)
2 stars: 1 (1%)
1 star: 1 (1%)

Serradefend

Very good product! It arrived quickly and it helps my candida very much. I combine it with the propobiotic.

Works great!

I have been taking Serra defend Digedtive enzyme capsules once daily empty stomach in the morning for over a month now along with other health supplements. I feel this product works amazingly great for people with digestive issues. It has helped me overcome my candida overgrowth and I just feel so blessed that I am able to atleast include certain food into my diet which I had to quit earlier.

Working!

Making prescription meds work better. Much relief.

I like the taste!

I've been using this product for 2 1/2 months. I take it when I wake up in the night, I'm sure it's on an empty stomach. I use it as support for my gut. I continue to be off my RA meds and feel good. I feel this product is an import component in my health plan.

Been taking it for 2 days and I noticed a difference in my body...I will be buying this again.

Can’t say for sure

I take it as directed, but whether it’s doing anything helpful or not, I cannot say for sure maybe after consuming the complete bottle I will have a different opinion.

It keeps my gut working as is supposed to be.

As I said in the title, it keeps my gut working on time, I do not feel bloated, and I am fine with it.

Helpful

This really helps me. I can tell if i dont take it for a day or so. I'm thankful for this product. It helps with digestion & it helps me with all around health. I appreciate this & their other products.

Great Enzyme

One of the best enzymes I have found. So far I have used it before bed as part of a biofilm cleanse. Will also try with meals at some point. Thankyou for the great products!!

Removed biofilm

I take one of these before bed, my nose usually opens up a bit about 20 minutes after taking it. I see mucus and biofilm looking stuff in my stools when taking this. It's working for sure.

Doing well thus far ☺️

Began taking it a couple weeks ago to support my Candida Cleanse journey. I can’t say I feel a difference, what I can say is my body is receiving it well.

I am also taking CandidAssist + CandiCleanse.

Serra Defend

Almost 1month. I’ve had this for awhile so this will take sometime. I’m optimistic.

Feeling the benefits of this addition- great help with digestion

I'm glad we added this supplement in!
Feelin better digestion with it!

Works!

I was having terrible itching all over my body from yeast overgrowth and this product is curing that. I now have a better quality of life. I recommend SerraDefend.

Too early to tell

I've only been taking this formula for a short while so it's too early to tell about the results; but I do like the all-in-one ingredients that saves me from buying multiple bottles of individual enzymes.

Review of SerraDefend

To Balance One. I appreciate SerraDefend. It helps to improve my digestion and reduces the Candida symptoms. Please keep making it!

Liver One

Love this product. It has been very helpful.

I find that it causes me to feel nauseous. It says to take on an empty stomach. Can I take it with food?

Thank you for your message. Some people are particularly sensitive to serrapeptase, one of the two proteolytic enzymes in SerraDefend, and this can sometimes lead to feelings of nausea—especially when taken on an empty stomach. While it’s designed to be taken without food for best results, it’s perfectly fine to take it with a small amount of food if that helps reduce discomfort. Since the standard dose is one capsule per day, another option is to take it every other day while your body adjusts. Please feel free to reach out if you have any other questions or need additional support.

Best,
Anna – Customer Service

The Best

Love my SerraDefend! I have tried so many digestive enzymes and this one is by far the best!

Working for me!

I have been having so much difficulty with Candida overgrowth and this has been such a game changer. Ordering more as we speak!

Review of Balance One Products

I do think they help, the enzymes look very good, I have not yet gotten rid of my yeast problem, but hope to soon be rid of it. So I do not fully know yet.

Thanks so much for your honest feedback! We're really glad to hear you're finding SerraDefend helpful so far. Enzymes like these can be a great part of your Candida-fighting toolkit, especially when combined with a low-sugar diet and the right antifungal support. Everyone’s journey looks a little different, and progress can take time — but you're on the right track. We're here for you if you ever have questions or need help along the way!
Best,
Anna - Customer Service

SerraDefend for gut

I have tried a bottle and seems to help with my digestion when I take it before breakfast. Would like to order more.

EXCELLENT PREBIOTIC!

In Nov. 2023, I purchased the Candida Cleanse system from Balance One, which was excellent. Part of the program included adding SerraDefend as a prebiotic, along with the Balance One probiotic. I've been using these 2 products for over a year now. They keep me regular and feeling no more belly bloating! Highly recommend.

Feel so much better now. So glad I ordered this product!

Serradefend

This is the 1st product that has helped my stomach settle down. Very happy with this, I can sleep!!!

Definitely add this!

I have been fighting candida overgrowth all year and the Serra defend definitely helps the gut feel better!

Candida biofilm

Been doing the lords work in getting rid of my candida biofilm highly suggest it!

Helpful for systemic Candida

I was recommended the BalanceOne probiotic alongside SerraDefend and have found both effective in easing the symptoms

Good

Seems like it worked well. Easy to swallow.

Great products

The balance one products are high quality and effective supplements. I have been taking them for a year and am very pleased with this company and their products.