NATURAL ENZYME BLEND | GENTLE AND EFFECTIVE

Balance ONE SerraDefend

$28.97

Enzymes do more than aid digestion—they support whole-body wellness.
SerraDefend combines systemic and digestive enzymes to promote healthy circulation, immune function, and gut balance.
Each bottle contains a 30-day supply. Made in the USA, third-party tested, non-GMO, and vegan.

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Balance ONE SerraDefend

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Key Ingredients

Pure Ingredients, Third Party Tested

Serrapeptase

A proteolytic enzyme originally derived from silkworms, serrapeptase helps break down unwanted protein structures and supports healthy circulation and tissue response.

Nattokinase

Sourced from fermented soybeans, nattokinase supports healthy blood flow and assists in breaking down excess fibrin in the body.

Protease

A broad-spectrum enzyme that helps digest protein and supports the breakdown of biofilms and other protein-based debris.

Cellulase

An enzyme that breaks down cellulose, helping to digest plant fibers and support overall gut function.

Hemicellulase

Works alongside cellulase to break down complex plant fibers and support a healthy digestive environment.

Chitosanase

Breaks down chitosan, a structural component in yeast cell walls, helping to disrupt biofilms and support microbial balance.

Amylase

A digestive enzyme that helps break down starches and carbohydrates into simpler sugars for better absorption.

Glucoamylase

Works with amylase to further break down complex carbohydrates, supporting healthy digestion and nutrient availability.

Beta-Glucanase

Targets beta-glucans found in fungal cell walls and grains, aiding in biofilm disruption and digestive comfort.

A Different Approach to Enzymes

SYSTEMIC & DIGESTIVE ENZYMES

SerraDefend features serrapeptase and nattokinase for systemic support, plus protease, cellulase, and other enzymes to aid digestion and help break down gut biofilms.

EASY TO SWALLOW CAPSULES

Easy-to-swallow capsules with no chalky texture or unpleasant aftertaste. Designed for daily use and gentle enough for sensitive stomachs.

100% NATURAL & NON-GMO

Made with clean ingredients—no fillers, artificial additives, or preservatives, and absolutely no genetically modified organisms.

GENTLE YET EFFECTIVE

Designed to deliver meaningful results without harsh side effects, offering strong support that’s easy for your body to tolerate.

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Product Information

Targeted Enzymes for Gut and Beyond
SerraDefend is a systemic and digestive enzyme formula designed to break down biofilms, support gut health, and reduce inflammation throughout the body.

Powerful Enzyme Blend
Each capsule delivers serrapeptase and nattokinase—enzymes known for their systemic anti-inflammatory effects—alongside a supporting cast of protease, cellulase, chitosanase, and others. Together, they help degrade biofilms, break down unwanted proteins, and support healthy circulation and immune response.

Support for Digestion, Inflammation, and Microbial Balance
By breaking down tough protein structures and microbial barriers, SerraDefend helps clear the way for better digestion and improved effectiveness of other supplements. It’s a great choice alongside a probiotic or antifungal regimen.

Clean Formula with Delayed-Release Capsules
Our delayed-release capsules protect the enzymes from stomach acid, allowing them to be absorbed into the bloodstream where they’re most effective. SerraDefend is vegan, non-GMO, and free from gluten, soy, and dairy.

Third-Party Tested and Made in the USA
Every batch is manufactured in a GMP-certified facility and third-party tested, so you can trust what you’re putting in your body.

The active ingredients in SerraDefend are:
Serrapeptase - 45,000 SPU
Nattokinase - 700 FU
Protease - 10,000 HUT
Cellulase - 5,000 CU
Hemicellulase - 5,000 HCU
Chitosanase - 50mg
Amylase - 12,000 DU
Glucoamylase - 15 AG
Beta-Glucanase - 70 BGU

Other ingredients in SerraDefend are:
Cellulose (Vegan Capsule), Maltodextrin (as a carrier for the enzymes).

Take one capsule daily on an empty stomach, or as directed by a healthcare professional.

SerraDefend can be taken alongside any of our other supplements. It does not interact with probiotics or antifungal supplements.

Serrapeptase
Shown to degrade bacterial biofilms and reduce inflammation, potentially boosting the effectiveness of antimicrobials against pathogens. [Source]

Nattokinase
This protease significantly disrupts biofilm matrices, especially by breaking down amyloid and fibrin components, making microbes more vulnerable. [Source]

Protease
Supplemental proteases improve gut barrier integrity and digestion while aiding removal of damaged protein debris that may support inflammation. [Source]

Cellulase
Demonstrated to disperse bacterial biofilms—especially from Pseudomonas and mycobacteria—by degrading structural cellulose in extracellular matrices. [Source]

Hemicellulase
Part of enzyme blends that effectively disrupt biofilms by breaking down hemicellulose components in bacterial and fungal extracellular matrices. [Source]

Chitosanase
Purified chitosanase significantly inhibited formation of both Gram-positive and Gram-negative bacterial biofilms in controlled studies. [Source]

Amylase
Amylase-rich enzyme blends positively influenced gut microbiome composition, likely via enhanced carbohydrate breakdown and reduced fermentation substrates. [Source]

Glucoamylase
Glucoamylase effectiveness in disrupting glycogen- or starch-based biofilms has been documented in microbial studies targeting extracellular polysaccharides. [Source]

Beta-Glucanase
Beta-glucanase is recognized for hydrolyzing fungal polysaccharide matrices, making it effective against fungal biofilms including Candida. [Source]

Frequently Asked Questions

SerraDefend combines systemic and digestive enzymes into one powerful formula designed to work both in your gut and throughout your body. It features serrapeptase and nattokinase—two well-studied enzymes known for breaking down proteins, fibrin, and biofilms—alongside a full spectrum of digestive enzymes. Unlike basic enzyme blends, SerraDefend is formulated for both digestive support and whole-body benefits like inflammation reduction and improved circulation. It’s made in the USA, third-party tested, vegan, and free of common allergens.

SerraDefend is rigorously tested both in-house and by an independent third-party lab. Every batch is made in GMP-certified facilities that meet the highest standards for safety and quality.

SerraDefend is made in California, USA, using high-quality ingredients sourced from around the world, in a GMP-certified, FDA-compliant facility. We use rigorous quality control on our ingredients and processes to ensure the highest standards.

Almost all enzyme formulations use maltodextrin as the carrier for their enzymes, even though some of them choose not to include it on their Supplement Facts label. Our enzymes are a liquid and are sprayed on to maltodextrin to keep them stable. The amount of maltodextrin used is small.

SerraDefend is completely free of nuts, wheat, gluten, soy, and dairy. It is vegan, completely non-GMO, and free from all preservatives and artificial colors or flavors. Our facilities are fully cGMP-compliant and operate to the highest standards. In addition, we use rigorous quality control to ensure that our supplements match what it says on the label.

SerraDefend does not need to be refrigerated. However, it will stay freshest when stored in a cool, dry place.

We recommend taking SerraDefend without food and at least one hour away from your meal. That will allow the systemic enzymes to pass through to your intestine safely. The exact time of day does not matter, but it should be at least an hour away from any meal.

The capsules we use for SerraDefend are 0.72in long and 0.42in wide. They're quite compact and most of our customers find them very easy to swallow.

Most people notice improvements within 1–2 weeks of consistent use, but this can vary depending on your health goals and how you're using SerraDefend (with or without food). For best results, we recommend taking it daily on an empty stomach, for at least 4–6 weeks.

For some people, enzyme formulations like SerraDefend can cause mild digestive symptoms at first. They might include gas, bloating or mild diarrhea. These symptoms usually pass within a few days.

If you are pregnant or breastfeeding, please consult your healthcare provider before using SerraDefend or any other supplement.