Berberine: A Multi-Purpose Herbal Supplement

by Katie Stone, ND June 24, 2020 4 min read

Berberine: A Multi-Purpose Herbal Supplement

Berberine is a multi-purpose, natural compound with a remarkable range of health-promoting properties.

Derived from herbs such as barberry, Oregon grape and goldenseal, berberine has been used to treat a variety of conditions, including skin disorders, digestive issues, and topical infections.

Berberine is also the main active component of the ancient Chinese herb Coptis chinensis, which has long been used as a way to manage blood sugar.

More recently, researchers have found that berberine demonstrates powerful antifungal properties, in some cases as potent as prescription drugs. Research has also shown that is can promote optimal cardiovascular health.

Berberine HCl is one of the ingredients in our Candida Cleanse formula. Let’s take a closer look at its potential health benefits.

What Does Berberine Do?

Manages Blood Sugar

Several studies have found that Berberine can help to regulate blood glucose levels and lipid metabolism in vitro, providing a glucose-lowering effect similar to that of metformin.

When tested in rats, berberine was found to increase the sensitivity of insulin, reducing insulin resistance.

In people with diabetes, berberine seems to help reduce blood sugar levels. Some studies have suggested that taking berberine daily for up to 3 months may help to control blood sugar as effectively as metformin or rosiglitazone. (4)

May Treat Type 2 Diabetes

Berberine HCI has a wide range of benefits and mechanisms of action for managing diabetes. It appears to have hypoglycemic effects by inhibiting alpha-glucosidase activity while also increasing the activity of insulin receptors in peripheral tissues. This has the effect of improving insulin sensitivity.

In addition, berberine HCI helps to activates Nrf2, a key regulator of cellular antioxidant defense mechanisms. It also improves glucose induced neurotoxicity, which may mean it can be used as a treatment for diabetic neuropathy.

Controlled trials of Berberine HCI have shown it to reduce HbA1c levels in diabetic participants almost as effectively as metformin. (X)

An Effective Antifungal

One of Berberine’s most interesting abilities is to prevent the spread of yeast and fungal organisms – including those resistant to drugs.

A 2016 study found that berberine has antifungal activity against several types of yeast, including fluconazole-resistant Candida. When researchers treated these resistant samples with berberine, it killed the yeast cells by altering the integrity of the plasma and mitochondrial membranes, possibly acting at specific sites near cell DNA. (1)

More recently, berberine has been found to work alongside pharmaceutical drugs such as fluconazole, enhancing the overall antifungal activity of the drug in fighting Candida.

Breaks Down Biofilms

One of the biggest challenges in treating fungal and bacterial infections is biofilms.

Infections with biofilms are difficult to treat because their microbial structures are resistant to the activity of common antimicrobial drugs. Candida albicans is one of the main pathogenic microorganisms that uses biofilms.

Studies have found that berberine can reduce the growth of planktonic cells (cells which stick together) and inhibit their ability to grow.

This finding is relevant because biofilms are frequently associated with reduced sensitivity to conventional antimicrobial agents. (2)

Improves Cardiovascular Health

Along with its many other health benefits, Berberine HCI may be an effective means of mitigating cardiometabolic disorders.

Researchers have found that Berberine targets multiple cardiometabolic risk factors in diabetes patients, including lowering total and LDL cholesterol. A clinical trial conduced on patients receiving percutaneous coronary intervention showed that berberine improved multiple inflammatory markers, including C-reactive protein.

In patients with metabolic syndrome, Berberine has been shown to reduce several risk factors such as waist circumference, body weight, blood pressure and triglycerides. It also helps to improve insulin resistance compared to placebo, particularly in women with PCOS.

Immune Booster

As well as killing off pathogenic fungi, yeast and bacteria, Berberine can also be used as a powerful immune stimulant.

It’s often used to treat and prevent colds and flu, as well as speeding recovery from infection. Its ability to activate macrophages (white blood cells) has been shown to enhance the body’s overall defense system, allowing it to fight off invading pathogens. It also helps to reduce the pro-inflammatory cytokines that aggravate infections and slow healing.

Berberine supplements derived from goldenseal appear to stimulate antimicrobial activity and also enhance immune response by stimulating increased antibody production. For this reason, berberine has been suggested for use in illnesses that are otherwise difficult to treat. 

Look for Berberine HCI

If you want to try berberine yourself, look for product containing Berberine HCI. This hydrochloride extract of berberine is the most potent and popular form of Berberine and is also the form used most often in clinical studies.  

Our Candida Cleanse formula contains Berberine HCl plus another 7 antifungal ingredients.

It’s not always easy to maintain a healthy balance of intestinal flora. An imbalance of Candida can cause problems with digestion and immunity. That’s why a balanced gut is so important to maintain good overall health.

 

Here are a few key reasons why Candida Cleanse is so effective:

  • 8 natural, antifungal ingredients to fight Candida:
    Caprylic Acid, Undecylenic Acid, Oregano Leaf Extract, Berberine HCl, Betaine HCl, NAC, Olive Leaf Extract, and Garlic Extract
  • Delayed-release capsules to get those ingredients safely to your gut
  • 90 delayed-release capsules per bottle (enough for a whole month)
  • Free of nuts, dairy, gluten, soy. Non-GMO and vegan.

You can read more about Candida Cleanse here. 

Katie Stone, ND
Katie Stone, ND



Also in Updates from Balance ONE

Prebiotics: Are They Always Necessary?
Prebiotics: Are They Always Necessary?

by Katie Stone, ND September 10, 2020 5 min read

Probiotics for H. Pylori
Probiotics for H. Pylori

by Katie Stone, ND September 08, 2020 6 min read

Why You Should Avoid Probiotic Gummies
Why You Should Avoid Probiotic Gummies

by Katie Stone, ND September 03, 2020 4 min read